7btd: Difference between revisions
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==Crystal structure of Rheb Y35N mutant bound to GppNHp== | ==Crystal structure of Rheb Y35N mutant bound to GppNHp== | ||
<StructureSection load='7btd' size='340' side='right'caption='[[7btd]]' scene=''> | <StructureSection load='7btd' size='340' side='right'caption='[[7btd]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BTD FirstGlance]. <br> | <table><tr><td colspan='2'>[[7btd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BTD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7btd OCA], [http://pdbe.org/7btd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7btd RCSB], [http://www.ebi.ac.uk/pdbsum/7btd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7btd ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHEB, RHEB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7btd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7btd OCA], [http://pdbe.org/7btd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7btd RCSB], [http://www.ebi.ac.uk/pdbsum/7btd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7btd ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RHEB_HUMAN RHEB_HUMAN]] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.<ref>PMID:12271141</ref> <ref>PMID:12869586</ref> <ref>PMID:15340059</ref> <ref>PMID:15854902</ref> <ref>PMID:16098514</ref> <ref>PMID:20381137</ref> | |||
==See Also== | |||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ding J]] | [[Category: Ding, J]] | ||
[[Category: Zhang C]] | [[Category: Zhang, C]] | ||
[[Category: Zhang T]] | [[Category: Zhang, T]] | ||
[[Category: Mtorc1]] | |||
[[Category: Rheb]] | |||
[[Category: Signaling protein]] | |||
[[Category: Small gtpase]] | |||
Revision as of 07:03, 30 December 2020
Crystal structure of Rheb Y35N mutant bound to GppNHp
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