Sandbox Reserved 1654

This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Cytplasmic Polyadenylation Element-binding Protein (CPEB)

You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue.

Structure

All CPEB proteins have a similar structure :

• A N-terminal region which is a regulatory region with phosphorylation and dephosphorylation sites. This region is variable in length and composition.
• A C-terminal region, composed of 2 recognition patterns (RRMs) which allow a good positioning of RNA, a high fidelity and are essential for the CPE specific recognition and of 2 zinc finger patterns, containing a specific RNA-binding protein sequence which play a role in affinity but not in specificity.

1. Zinc finger patterns

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

1. RRMs patterns

Disease

This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.