Sandbox Reserved 1654: Difference between revisions
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== Structure == | == Structure == | ||
All CPEB proteins have a similar structure : | All <scene name='86/868187/Zz/3'>CPEB proteins</scene> have a similar structure : | ||
* A N-terminal region which is a regulatory region with phosphorylation and dephosphorylation sites. This region is variable in length and composition. | * A N-terminal region which is a regulatory region with phosphorylation and dephosphorylation sites. This region is variable in length and composition. | ||
* A C-terminal region, composed of 2 recognition patterns (RRMs which allow a good positioning of RNA, a high fidelity and are essential for the CPE specific recognition) and 2 zinc finger patterns (containing two zinc binding sites and a specific RNA-binding protein sequence which play a role in affinity but not in specificity). | * A C-terminal region, composed of 2 recognition patterns (RRMs which allow a good positioning of RNA, a high fidelity and are essential for the CPE specific recognition) and 2 zinc finger patterns (containing two zinc binding sites and a specific RNA-binding protein sequence which play a role in affinity but not in specificity). | ||
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***A <scene name='86/868187/310/1'>3<sub>10</sub> helical turn</scene> (residues 550-552). | ***A <scene name='86/868187/310/1'>3<sub>10</sub> helical turn</scene> (residues 550-552). | ||
***2 zinc binding sites, the first one is composed of <scene name='86/868187/Z1/1'>Cys515, Cys518, Cys537, Cys540</scene> and the second is composed of <scene name='86/868187/Z2/1'>Cys527, Cys532, His545 and His553</scene>. | ***2 zinc binding sites, the first one is composed of <scene name='86/868187/Z1/1'>Cys515, Cys518, Cys537, Cys540</scene> and the second is composed of <scene name='86/868187/Z2/1'>Cys527, Cys532, His545 and His553</scene>. | ||
** RRMs patterns | ** '''RRMs patterns''' | ||
