Sandbox Reserved 1652: Difference between revisions
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’’Phosphorylation’’’ of the TRPV1 receptor leads to its sensitization. | ’’Phosphorylation’’’ of the TRPV1 receptor leads to its sensitization. | ||
Phosphorylations occurs on multiple phosphorylation sites at both N-terminal and C-terminal sites of TRPV1 by [https://en.wikipedia.org/wiki/Kinase kinases]. Phosphorylations are either caused by PKC (IP3 signalling), by PKA (AMPc signalling) or by CamKII an PI3K.<ref>K. W. Ho, N. J. Ward, et D. J. Calkins, « TRPV1: a stress response protein in the central nervous system », Am. J. Neurodegener. Dis., vol. 1, no 1, p. 1‑14, avr. 2012.</ref> | Phosphorylations occurs on multiple phosphorylation sites at both N-terminal and C-terminal sites of TRPV1 by [https://en.wikipedia.org/wiki/Kinase kinases]. Phosphorylations are either caused by PKC (IP3 signalling), by PKA (AMPc signalling) or by CamKII an PI3K.<ref>K. W. Ho, N. J. Ward, et D. J. Calkins, « TRPV1: a stress response protein in the central nervous system », Am. J. Neurodegener. Dis., vol. 1, no 1, p. 1‑14, avr. 2012.</ref><ref>G. Smutzer et R. K. Devassy, « Integrating TRPV1 Receptor Function with Capsaicin Psychophysics », Advances in Pharmacological Sciences, janv. 14, 2016.</ref> | ||
<ref>G. Smutzer et R. K. Devassy, « Integrating TRPV1 Receptor Function with Capsaicin Psychophysics », Advances in Pharmacological Sciences, janv. 14, 2016.</ref> | |||
PKC phosphorlyates TRPV1 at S800,S502, PKA phosphorylates TRPV1 at S116. | PKC phosphorlyates TRPV1 at S800,S502, PKA phosphorylates TRPV1 at S116. | ||
