Sandbox Reserved 1652: Difference between revisions
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=== Activators === | === Activators === | ||
#Capsaicin | |||
[[Image:128px-Capsaicin Formulae.png | thumb|Chemical structure of capsaicin]] | [[Image:128px-Capsaicin Formulae.png | thumb|Chemical structure of capsaicin]] | ||
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Capsaicin maintains TRPV1 in an open state by «pull and contact» interactions. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. This leads to the massive enter of Ca2+ and Na+ in the cytoplasm of the nerve fiber and to the depolarization of the nerve fiber. When depolarization reach a theshold value it triggers the generation of an [https://en.wikipedia.org/wiki/Action_potential action potential] causing a painful sensation.<ref>« TRPV1 », Wikipédia. sept. 09, 2020, Consulté le: déc. 28, 2020. [En ligne]. Disponible sur: https://fr.wikipedia.org/w/index.php?title=TRPV1&oldid=174570512</ref> | Capsaicin maintains TRPV1 in an open state by «pull and contact» interactions. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. This leads to the massive enter of Ca2+ and Na+ in the cytoplasm of the nerve fiber and to the depolarization of the nerve fiber. When depolarization reach a theshold value it triggers the generation of an [https://en.wikipedia.org/wiki/Action_potential action potential] causing a painful sensation.<ref>« TRPV1 », Wikipédia. sept. 09, 2020, Consulté le: déc. 28, 2020. [En ligne]. Disponible sur: https://fr.wikipedia.org/w/index.php?title=TRPV1&oldid=174570512</ref> | ||
#Resiniferatoxin (RTX) | |||
[[Image:Resiniferatoxin.png | thumb | Chemical structure of resiniferatoxine]] | [[Image:Resiniferatoxin.png | thumb | Chemical structure of resiniferatoxine]] | ||
