Sandbox Reserved 1653: Difference between revisions
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Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo 1 is involved is shear stress sensing | Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo 1 is involved is shear stress sensing | ||
in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [ | in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [https://en.wikipedia.org/wiki/Hypertension hypertension]. It’s also involved in red blood cell volume homeostasis. <ref name="Cell Press"/> | ||
Piezo channel mediated cationic [non selective currents]. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | Piezo channel mediated cationic [non selective currents]. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | ||
However, Piezo 1 is implicated in [excitatory channels] because cation can enter into the cell and lead to membrane [depolarisation] or [calcium dependent signalling pathway] (if Ca2+ enter). | However, Piezo 1 is implicated in [excitatory channels] because cation can enter into the cell and lead to membrane [depolarisation] or [calcium dependent signalling pathway] (if Ca2+ enter). | ||
