Sandbox Reserved 1652: Difference between revisions
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Stimulation by resiniferatoxin makes this ion channel permeable to cations, especially calcium. | Stimulation by resiniferatoxin makes this ion channel permeable to cations, especially calcium. | ||
The pocket size characteristics of the TRPV1-RTX allow the installation of large structures such as the RTX : The '''sub-pocket''' near <scene name='86/868185/Y511/2'>Y511</scene> is shallow in the TRPV1-RTX because <scene name='86/868185/Y511/2'>Y511</scene> and <scene name='86/868185/E570/2'>E570</scene> are close and I569 is oriented towards the vanilloid pocket. | The pocket size characteristics of the TRPV1-RTX allow the installation of large structures such as the RTX : The '''sub-pocket''' near <scene name='86/868185/Y511/2'>Y511</scene> is shallow in the TRPV1-RTX because <scene name='86/868185/Y511/2'>Y511</scene> and <scene name='86/868185/E570/2'>E570</scene> are close and <scene name='86/868185/I569/1'>I569</scene> is oriented towards the vanilloid pocket. | ||
The sub-pocket near L669, V583, and F587 is wide due to the projection of these amino acids out of the vanilloid pocket. This sub-pocket accommodates the [https://en.wikipedia.org/wiki/Diterpene diterpene] group of the RTX. | The sub-pocket near L669, V583, and F587 is wide due to the projection of these amino acids out of the vanilloid pocket. This sub-pocket accommodates the [https://en.wikipedia.org/wiki/Diterpene diterpene] group of the RTX. | ||
However, the orientation of L515 and M547 makes this region of the vanilloid pocket narrow, which considerably limits the nature of the fragments tolerated. | However, the orientation of L515 and M547 makes this region of the vanilloid pocket narrow, which considerably limits the nature of the fragments tolerated. | ||
