Sandbox Reserved 1653: Difference between revisions
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The subcellular localisation of piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | The subcellular localisation of piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | ||
However, piezo1 is also able to drive endothelial cell migration without shear stress, through endothelial nitric oxide synthase, a protein with major | However, piezo1 is also able to drive endothelial cell migration without shear stress, through endothelial nitric oxide synthase, a protein with major | ||
roles in vascular biology. | roles in vascular biology. <ref name= "vascularisation"> DOI 10.1038/nature13701</ref> | ||
