Sandbox Reserved 1653: Difference between revisions

The <scene name='86/868186/Ion_conducting_pore/1'>central pore axis</scene> of piezo1 is lined with the <scene name='86/868186/Ced/1'>extracellular cap domain</scene>, inner helix and cytosolic <scene name='86/868186/Ctd/1'>CTD</scene>. The extracellular cations can approach the pore entry “vertically through the internal cavity along the threefold axis of the cap domain”, they can also approach laterally through spaces (gaps) between the flexible linkers which connect the cap with inner and outer helices.<ref name= "ion channel"> DOI 10.1038/nature25453</ref> The <scene name='86/868186/Ion_conducting_pore/1'>ion conduction pathway</scene> is situated below the <scene name='86/868186/Ced/1'>cap</scene>, and is  

lined by the three inner transmembrane helices. The possible access for lipids or other hydrophobic molecules through the pore could be “two lateral openings between the inner helices separated by a ‘seal’ formed by K2479 and F2480”. These openings are approximately 11 Å wide and 16 Å tall. <ref name= "ion channel">

==='''CTD and Beam'''===