Sandbox Reserved 1658: Difference between revisions

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<p align="justify"> For exemple, the semaphorins (SEMA) bind to the (a1/a2/b1) domains while Vascular endothelial growth factors (VEGFs) bind to (b1/b2). The c domain as well as the transmembrane domain, are involved in the receptor dimerization.</p>

In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.

<p align="justify">In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.

The a1 and a2 domains are CUB domains and include <scene name='86/868191/Calcium_binding_site/1'>Calcium binding site</scene>. The ion is coordinated by two carbonyl oxygens from Ala(252)and Ile(253) and by three negatively charged side chains (Glu(195),Asp(209) and Asp(250)).

On an other side, b1 and b2 form a jellyroll <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.

On an other side, b1 and b2 form a jellyroll <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>

Sandbox Reserved 1658: Difference between revisions

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@@ Line 18: / Line 18: @@
 <p align="justify"> For exemple, the semaphorins (SEMA) bind to the (a1/a2/b1) domains while Vascular endothelial growth factors (VEGFs) bind to (b1/b2). The c domain as well as the transmembrane domain, are involved in the receptor dimerization.</p>
-In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.
+<p align="justify">In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.
 The a1 and a2 domains are CUB domains and include <scene name='86/868191/Calcium_binding_site/1'>Calcium binding site</scene>. The ion is coordinated by two carbonyl oxygens from Ala(252)and Ile(253) and by three negatively charged side chains (Glu(195),Asp(209) and Asp(250)).
-On an other side, b1 and b2 form a jellyroll <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.
+On an other side, b1 and b2 form a jellyroll <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>