Sandbox Reserved 1653: Difference between revisions

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Piezo 1 is a [https://en.wikipedia.org/wiki/Mechanosensitive_channels mechanosensitive channel] which means, it can sense external mechanical forces such as fluid flow-induced shear stress,

osmotic stress, and pressure-induced membrane stretch ~~[1]~~. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”. Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. <ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref>

osmotic stress, and pressure-induced membrane stretch. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”.<ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref> Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. <ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref>

For the “force-from-lipids” mechanism, membrane tension is induced by mechanical forces. This membrane tension leads to a reorganization of lipids within and surrounding the channel proteins. This reorganization of lipids results into membrane lipid-channel protein interactions that induce the channel to open. We can note that a recent study (Lin et al., 2019)<ref name= "Lin"> DOI 10.1038/s41586-019-1499-2 </ref> gave support to this mechanism.

Sandbox Reserved 1653: Difference between revisions

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 Piezo 1 is a [https://en.wikipedia.org/wiki/Mechanosensitive_channels mechanosensitive channel] which means, it can sense external mechanical forces such as fluid flow-induced shear stress,
-osmotic stress, and pressure-induced membrane stretch [1]. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”. Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. <ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref>
+osmotic stress, and pressure-induced membrane stretch. Moreover, “studies have demonstrated wide expression of the Piezo1 channel that enables many different types of cells to sense a diversity of “outside-in” mechanical forces, including indentation, membrane stretch, shear stress, osmotic stress, ultrasound, and compression”.<ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref> Since piezo 1 channel could also be activated by traction forces, there are two different mechanisms that have been proposed to explain the mechanical activation of piezo 1 channel. These mechanisms are called “force-from-lipids” and “force-from-filaments”. <ref name= "Adenosine"> DOI 10.3389/fphar.2019.01304</ref>
 For the “force-from-lipids” mechanism, membrane tension is induced by mechanical forces. This membrane tension leads to a reorganization of lipids within and surrounding the channel proteins. This reorganization of lipids results into membrane lipid-channel protein interactions that induce the channel to open. We can note that a recent study (Lin et al., 2019)<ref name= "Lin"> DOI 10.1038/s41586-019-1499-2 </ref> gave support to this mechanism.