Sandbox Reserved 1654: Difference between revisions
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{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==Cytoplasmic Polyadenylation Element-Binding Protein (CPEB)== | ==Cytoplasmic Polyadenylation Element-Binding Protein (CPEB)== | ||
[https://en.wikipedia.org/wiki/CPEB CPEB ](Cytoplasmic polyadenylation element binding protein) is present in most vertebrates and invertebrates and can activate or inhibit translation, depending on the different factors it can bind <ref>DOI 10.1016/j.tibs.2007.04.004</ref>. In human body there are 4 different isoforms of CPEB (CPEB1 to CPEB4), distributed throughout body in a tissue-dependent manner and which interact differently with mRNA <ref>DOI 10.1016/j.arr.2012.03.004</ref>. | [https://en.wikipedia.org/wiki/CPEB CPEB ](Cytoplasmic polyadenylation element binding protein) is present in most vertebrates and invertebrates and can activate or inhibit translation, depending on the different factors it can bind <ref>DOI 10.1016/j.tibs.2007.04.004</ref>. In human body there are 4 different isoforms of CPEB (CPEB1 to CPEB4), distributed throughout body in a tissue-dependent manner and which interact differently with mRNA <ref name="publi">DOI 10.1016/j.arr.2012.03.004</ref>. | ||
CPEB protein regulates the length of the polyA tail which allows to control the translation. It binds to mRNA and in association with some factors, can act as a translational repressor or activator, depending on these factors. | CPEB protein regulates the length of the polyA tail which allows to control the translation. It binds to mRNA and in association with some factors, can act as a translational repressor or activator, depending on these factors. | ||
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== Function == | == Function == | ||
CPEB controls the balance between senescence and proliferation. Indeed, due to its two structural domains in its C-terminal region, it has the capacity to modify mRNA< | CPEB controls the balance between senescence and proliferation. Indeed, due to its two structural domains in its C-terminal region, it has the capacity to modify mRNA<ref name="publi" />. | ||
RRMs domains allow binding to the CPE sequence of mRNA (pyrimidine rich : UUUUUAU), thus ensuring good RNA positioning and high fidelity. | RRMs domains allow binding to the CPE sequence of mRNA (pyrimidine rich : UUUUUAU), thus ensuring good RNA positioning and high fidelity. | ||
Zing finger domains allow binding to different proteins, which play a role in affinity but not in specificity. It's therefore its ability to recruit different proteins that will determine its action, activation or repression of translation. | Zing finger domains allow binding to different proteins, which play a role in affinity but not in specificity. It's therefore its ability to recruit different proteins that will determine its action, activation or repression of translation. | ||
