Sandbox Reserved 1660: Difference between revisions
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== Function == | == Function == | ||
=== Role in the immune system === | ==== Role in the immune system ==== | ||
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=== Ligands presented by CD1d === | ==== Ligands presented by CD1d ==== | ||
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== Impact of ligand-binding == | == Impact of ligand-binding == | ||
=== Conformational variation === | ==== Conformational variation ==== | ||
=== CD1d affinity === | <p align="justify"> | ||
NTK cells are a subset of T cells (which play a central role in immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the cytokine release (cell signaling). Conformational variation that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR. | |||
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==== CD1d affinity ==== | |||
<ref>{{Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added [https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ] (accessed Dec 5, 2020).}}</ref> | <ref>{{Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added [https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ] (accessed Dec 5, 2020).}}</ref> | ||
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== Appications == | == Appications == | ||
=== Immunotherapeutic tool === | ==== Immunotherapeutic tool ==== | ||
==== NKT cells marker ==== | |||
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CD1 molecules can also be used as NKT cell markers. Indeed, a CD1 molecule can be engineered to become fluorescent by binding a fluorescent-potent molecule to it. When the engineered complex interacts with a NKT cell, the fluorescent signal is emitted and therefore the NKT cells can be spotted. | |||
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==See Also== | ==See Also== | ||
