Sandbox Reserved 1660: Difference between revisions
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::- an alpha chain (T-cell surface glycoprotein CD1d1) of 287 amino acids <br> | ::- an alpha chain (T-cell surface glycoprotein CD1d1) of 287 amino acids <br> | ||
::- a beta-2-microglobulin chain of 99 amino acids. <br> | ::- a beta-2-microglobulin chain of 99 amino acids. <br> | ||
The first chain is made of two beta-sheets and a set of 2 alpha-helices. Each beta-sheet contains four antiparallel strands. | The first chain is made of two beta-sheets and a set of 2 alpha-helices. Each beta-sheet contains four antiparallel strands. The total molecular weight of the alpha chain is 33 kDa when not associated to any oligosaccharide and 55 kDa when the five oligosaccharides are associated to the chain. | ||
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Additionally, there are two oligosaccharides bound to the alpha chain via N-glycosylations and three types of small molecules bound to that protein. The overall structure of CD1d protein is akin to class I MHC’s molecules. Notwithstanding, the cleft where the ligand can bind its protein is different between MHC molecules and CD1d molecules. Indeed, the hydrophobic cleft of CD1d has a narrow opening. | |||
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== Impact of ligand-binding == | == Impact of ligand-binding == | ||
