Sandbox Reserved 1653: Difference between revisions
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==='''Gating mechanism'''=== | ==='''Gating mechanism'''=== | ||
[[Image:PIEZO_8.jpg#filehistory | thumb | upright=3 | Representation of the Gating Mechanism]] | |||
[[IImage:PIEZO.jpg#filehistory | thumb | upright=10| Representation of the Gating Mechanism]] | |||
Piezo1 possesses delicate force sensing and mechanotransduction mechanisms. Here, we explain how Piezo1 channels sense and transduce mechanical force | Piezo1 possesses delicate force sensing and mechanotransduction mechanisms. Here, we explain how Piezo1 channels sense and transduce mechanical force | ||
to gate the central ion-conducting pore. | to gate the central ion-conducting pore. | ||
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The structure of Piezo1 offers a plausible explanation for the origin of its tension [https://en.wikipedia.org/wiki/Gating_(electrophysiology)gating]. Indeed, if the semi-spherical dome becomes flatter when Piezo1 opens, then the channel membrane system will expand thanks to the flexibility of the blades. | The structure of Piezo1 offers a plausible explanation for the origin of its tension [https://en.wikipedia.org/wiki/Gating_(electrophysiology)gating]. Indeed, if the semi-spherical dome becomes flatter when Piezo1 opens, then the channel membrane system will expand thanks to the flexibility of the blades. | ||
However, because flattening does not constrain the pore to open wide, expansion and pore diameter are decoupled such that Piezo1 can exhibit is small conductance and cation selectivity, properties that are essential to its function.<ref name ="Piezo Senses Tension"/>,<ref name="Fanny"> DOI 10.1038/s41586-019-1499-2</ref> | However, because flattening does not constrain the pore to open wide, expansion and pore diameter are decoupled such that Piezo1 can exhibit is small conductance and cation selectivity, properties that are essential to its function.<ref name ="Piezo Senses Tension"/>,<ref name="Fanny"> DOI 10.1038/s41586-019-1499-2</ref> | ||
