Sandbox Reserved 1660: Difference between revisions
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NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the cytokine release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR. | NTK cells are a subset of [https://en.wikipedia.org/wiki/T_cell T cells] (which play a central role in the immune response) that are activated by CD1d-glycolipid complexes. α-GalCer is a potent NKT cell agonist when presented by CD1d. The stability of the CD1d-glycolipid complexes has an impact on the cytokine release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR. | ||
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<scene name='86/868193/Morph_3gmq_3gmn_u4681/5'>Conformational variations</scene> | |||
==== CD1d affinity ==== | ==== CD1d affinity ==== | ||
