Sandbox Reserved 1653: Difference between revisions
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Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo1 is involved in shear stress sensing in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [https://en.wikipedia.org/wiki/Hypertension hypertension]. It is also involved in the homeostasis of the volume of red blood cells.<ref name="Cell Press"/> | Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo1 is involved in shear stress sensing in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [https://en.wikipedia.org/wiki/Hypertension hypertension]. It is also involved in the homeostasis of the volume of red blood cells.<ref name="Cell Press"/> | ||
Piezo1 channel-mediated cationic non-selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | Piezo1 channel-mediated cationic non-selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | ||
However, Piezo1 is implicated in excitatory channels because | However, Piezo1 is implicated in excitatory channels because cations can enter into the cells and lead to the membrane [https://en.wikipedia.org/wiki/Depolarization depolarisation] or [https://en.wikipedia.org/wiki/Calcium_signaling calcium-dependent signalling pathway] (if Ca2+ enters).<ref name="Adenosine"> DOI 10.3389/fphar.2019.01304 </ref> | ||
When calcium-dependent signalling pathway is activated, NO can be released by endothelial cells and | When calcium-dependent signalling pathway is activated, NO can be released by endothelial cells and leads to vasodilation but also, some channels can be activated in red blood cells.<ref name="Adenosine"/> | ||
Piezo1 has a wide variety of functions, but we will focus on the vascularisation. | Piezo1 has a wide variety of functions, but we will focus on the vascularisation. | ||
