Sandbox Reserved 1653: Difference between revisions
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A deficit in Piezo1’s expression can lead to a cobblestone-like appearance of endothelial cells’ organisation, instead of its standard linear appearance. | A deficit in Piezo1’s expression can lead to a cobblestone-like appearance of endothelial cells’ organisation, instead of its standard linear appearance. | ||
The subcellular localisation of Piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, Piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | The subcellular localisation of Piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, Piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | ||
However, Piezo1 is also able to drive endothelial | However, Piezo1 is also able to drive endothelial cells migration without shear stress, through endothelial [https://en.wikipedia.org/wiki/Nitric_oxide_synthasenitric oxide synthase], a protein with major roles in vascular biology.<ref name= "vascularisation"> DOI 10.1038/nature13701</ref> | ||
