Sandbox Reserved 1658: Difference between revisions
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== Role in covid contamination == | == Role in covid contamination == | ||
The Neuropilin 1 is one of the entry site of the [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 SARS-CoV-2] in the cells. Indeed autopsies revealed that SARS-CoV-2 infects NRP1-positive cells facing the nasal cavity. | The Neuropilin 1 is one of the entry site of the [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 SARS-CoV-2] in the cells. Indeed autopsies revealed that SARS-CoV-2 infects NRP1-positive cells facing the nasal cavity. | ||
Unlike the SARS-Cov, SARS-CoV-2 owns a polybasic furin-type cleavage site at the S1-S2 junction in the [https://en.wikipedia.org/wiki/Peplomer spike protein(S)]. Or it was already known, that NRP1 binds [[furin]]-cleaved substrates. | Unlike the SARS-Cov, SARS-CoV-2 owns a polybasic furin-type cleavage site at the S1-S2 junction in the [https://en.wikipedia.org/wiki/Peplomer spike protein(S)]. Or it was already known, that NRP1 binds [[furin]]-cleaved substrates. The cleavage of the spike protein causes the formation of a C-terminal motif which observes the Cend rule. This motif is responsible for the binding of the virus on the b1 domain of NRP1. | ||
== Applications == | == Applications == | ||
