Sandbox Reserved 1656: Difference between revisions
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The involvement of deubiquitinases in diseases is still poorly understood. However, it is known that they play a role in various physiological processes, particularly in the case of cancers. <ref>PMID:19007433</ref> | The involvement of deubiquitinases in diseases is still poorly understood. However, it is known that they play a role in various physiological processes, particularly in the case of cancers. <ref>PMID:19007433</ref> | ||
In fact, DUBs have a role in the mechanism involved in histone modification and so have influence on tumor development and progression. For instance, in gastric cancer, DUBs are regulated upwards and DUBs are related to tumor size. <ref>PMID:31897112</ref> | In fact, DUBs have a role in the mechanism involved in histone modification and so have influence on tumor development and progression. For instance, in gastric cancer, DUBs are regulated upwards and DUBs are related to tumor size. <ref>PMID:31897112</ref> | ||
==== Otubain 1 ==== | |||
The enzyme Otubain 1 is a deubiquitinase belonging to the Otubain family of proteases. The role of OTUB1 is not yet clearly defined, some studies show the correlation between tumour growth and OTUB1 while others show no involvement or suppression of the tumour by this enzyme. This suggests that the effects of OTUB1 depend on the stage and the tumour itself. However, the therapeutic targeting of OTUB1 could be used for patients with various tumours, since the enzyme is found in many tissues and has a high level of cell expression. <ref>PMID:30400005</ref> | |||
== Structural highlights == | == Structural highlights == | ||
