Sandbox Reserved 1654: Difference between revisions
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***Trp331 makes key interactions to position RRM2 relative to RRM1 by inserting its indole ring between the beta sheet and alpha1 helix of RRM2. ***After the helical turn, the interdomain linker folds in a beta strand that runs anti-parallel to the beta2 strand (RRM2) and packs against the alpha1 helix of RRM2. Finally, the interdomain linker runs across the RRM2 beta sheet. Therefore, the interdomain linker acts as a hinge to fix the relative orientation of the two RRMs. | ***Trp331 makes key interactions to position RRM2 relative to RRM1 by inserting its indole ring between the beta sheet and alpha1 helix of RRM2. ***After the helical turn, the interdomain linker folds in a beta strand that runs anti-parallel to the beta2 strand (RRM2) and packs against the alpha1 helix of RRM2. Finally, the interdomain linker runs across the RRM2 beta sheet. Therefore, the interdomain linker acts as a hinge to fix the relative orientation of the two RRMs. | ||
<scene name='86/868187/Slt/2'>bonjour</scene> | |||
== Function == | == Function == | ||
