Sandbox Reserved 1654: Difference between revisions
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RRMs are necessary and sufficient for the CPE sequence recognition on RNA. They bind to RNA with high affinity and allow the RNA to take the good position. RRM1 binds to the four first RNA nucleotides (UUUU) and RRM2 binds to the 3' adenine of CPE. The two RRMs take a V-shaped conformation, facing to each other: | RRMs are necessary and sufficient for the CPE sequence recognition on RNA. They bind to RNA with high affinity and allow the RNA to take the good position. RRM1 binds to the four first RNA nucleotides (UUUU) and RRM2 binds to the 3' adenine of CPE. The two RRMs take a V-shaped conformation, facing to each other: | ||
***<scene name='86/868187/Rmm/4'>RRM1</scene> has anti-parallel beta strands between the alpha helix and the beta4 strand. | ***<scene name='86/868187/Rmm/4'>RRM1</scene> has anti-parallel beta strands between the <scene name='86/868187/Rmm/7'>alpha helix</scene> and the beta4 strand. | ||
***The <scene name='86/868187/Rmm/3'>interdomain linker</scene> takes a helical turn that interacts with residues of the N-terminal extension and with <scene name='86/868187/Rmm/6'>RRM2</scene>. | ***The <scene name='86/868187/Rmm/3'>interdomain linker</scene> takes a helical turn that interacts with residues of the N-terminal extension and with <scene name='86/868187/Rmm/6'>RRM2</scene>. | ||
***<scene name='86/868187/Rmm/1'>Trp331</scene> positions RRM2 relative to RRM1 by inserting its indole ring between the beta sheet and alpha1 helix of RRM2. | ***<scene name='86/868187/Rmm/1'>Trp331</scene> positions RRM2 relative to RRM1 by inserting its indole ring between the beta sheet and alpha1 helix of RRM2. | ||
