Sandbox Reserved 1645: Difference between revisions
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== Biological Function == | == Biological Function == | ||
Fibrillin-1 is a ubiquitous protein mostly expressed in muscles in its monomeric form. The monomers then polymerize to form the 10 to 12nm of diameter '''microfibrils'''. In the microfibrils the fibrillin-1 is associated to various proteins such as [[MAGP-1]], [[MAGP-2]], [[fibulin 2]] and [[fibulin 5]], [[elastin]], [[versicane]] and [[LTBP-1]]. Those microfibrils constitute the elastic and non-elastic human connective tissues such as the dermis or the organs. This protein plays an important role in the [ | Fibrillin-1 is a ubiquitous protein mostly expressed in muscles in its monomeric form. The monomers then polymerize to form the 10 to 12nm of diameter '''microfibrils'''. In the microfibrils the fibrillin-1 is associated to various proteins such as [[MAGP-1]], [[MAGP-2]], [[fibulin 2]] and [[fibulin 5]], [[elastin]], [[versicane]] and [[LTBP-1]]. Those microfibrils constitute the elastic and non-elastic human connective tissues such as the dermis or the organs. This protein plays an important role in the [https://en.wikipedia.org/wiki/Cytokine cytokine] and growth factor regulation. <ref>Julien Wipff, Yannick Allanore, and Catherine Boileau. (2009). Interactions entre la Fibrilline-1 et le TGF-β. ''Médecine Sciences Paris'', volume (25). https://www.medecinesciences.org/en/articles/medsci/full_html/2009/02/medsci2009252p161/medsci2009252p161.html</ref> | ||
== Disease caused by mutation == | == Disease caused by mutation == | ||
