Sandbox Reserved 1650: Difference between revisions
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Each of its monomers comprises 5 distinct regions on which approximately <scene name='86/868183/Tyr/1'>66 tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | Each of its monomers comprises 5 distinct regions on which approximately <scene name='86/868183/Tyr/1'>66 tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions : | ||
<scene name='86/868183/Ntd/3'>N-terminal Domain</scene> [[https://www.youtube.com/watch?v=MuFHlCZCetU&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=5>NTD]], <scene name='86/868183/Core/2'>Core</scene> [[https://www.youtube.com/watch?v=Lx1G1KGxKN8&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=8>CORE]], <scene name='86/868183/Flap/1'>Flap</scene> [[https://www.youtube.com/watch?v=vk60Rdyo28A&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=6>FLAP]], <scene name='86/868183/Arm/1'>Arm</scene> [[https://www.youtube.com/watch?v=XzeTjQKfO0E&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=9>ARM]] and <scene name='86/868183/Ctd/1'>C-terminal Domain</scene> [[https://www.youtube.com/watch?v=N-mg_xj-deI&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=7>CTD]]. | <scene name='86/868183/Ntd/3'>N-terminal Domain</scene> [[https://www.youtube.com/watch?v=MuFHlCZCetU&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=5>NTD]], <scene name='86/868183/Core/2'>Core</scene> [[https://www.youtube.com/watch?v=Lx1G1KGxKN8&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=8>CORE]], <scene name='86/868183/Flap/1'>Flap</scene> [[https://www.youtube.com/watch?v=vk60Rdyo28A&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=6>FLAP]], <scene name='86/868183/Arm/1'>Arm</scene> [[https://www.youtube.com/watch?v=XzeTjQKfO0E&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=9>ARM]] and <scene name='86/868183/Ctd/1'>C-terminal Domain</scene> [[https://www.youtube.com/watch?v=N-mg_xj-deI&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=7>CTD]]. | ||
In addition, TG has about 120 cysteine residues allowing the formation of about 60 disulfide bridge bonds per monomer. It is therefore a very stable and soluble protein. | In addition, TG has about 120 cysteine residues allowing the formation of about 60 disulfide bridge bonds per monomer [[https://www.youtube.com/watch?v=Nuryu1aSqvY&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=11>Disulfide bridge]]. It is therefore a very stable and soluble protein. | ||
=== Post-translational modifications === | === Post-translational modifications === | ||
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There are 7 hormonogenic sites for TG : | There are 7 hormonogenic sites for TG : | ||
two A sites, comprising two fixed donor tyrosines Y234 and Y149 and one flexible acceptor tyrosine: T24 | two A sites, comprising two fixed donor tyrosines Y234 and Y149 and one flexible acceptor tyrosine: T24 [[https://www.youtube.com/watch?v=98MKFRc6S_w&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=4>SIte A]] | ||
two B sites, including one Y2573 donor and one Y2540 acceptor | two B sites, including one Y2573 donor and one Y2540 acceptor [[https://www.youtube.com/watch?v=aNd32NLk9Fk&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=3>Site B]] | ||
a C site, comprising both donor and acceptor tyrosine Y2766 | a C site, comprising both donor and acceptor tyrosine Y2766 | ||
two D sites, comprising a Y108 donor and a Y1310 acceptor | two D sites, comprising a Y108 donor and a Y1310 acceptor [[https://www.youtube.com/watch?v=JYUPk59lVVw&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=2>Site D]] | ||
An acidic Asp or Glu residue always precedes the acceptor and a lysine is always close to the donor. | An acidic Asp or Glu residue always precedes the acceptor and a lysine is always close to the donor. | ||
