Sandbox Reserved 1653: Difference between revisions
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<references/><StructureSection load='5z10' size='350' side='right' caption='Structure of | <references/><StructureSection load='5z10' size='350' side='right' caption='Structure of the mechanosensitive Piezo1 channel 1 from PDB' scene=''> | ||
Piezo1 proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo1 is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs.<ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 </ref>,<ref name = "Cell Press"> DOI 10.1016/j.cub.2017.01.048 </ref> | Piezo1 proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo1 is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs.<ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 </ref>,<ref name = "Cell Press"> DOI 10.1016/j.cub.2017.01.048 </ref> | ||
