Sandbox Reserved 1649: Difference between revisions
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== Structure and Function == | == Structure and Function == | ||
NR2A (GluN2A) is composed of Amino-terminal domain (ATD), segments S1 and S2 which formed ligand binding domain of glutamate, three transmembrane helices (M1, M3,and M4), cytoplasmic re-entrant pore loop (M2), and an intracellular C-terminal domain (CTD). [[Image:StructureNR2A.jpg#filehistory]| thumb |left|400px| upright=10| '''Structure of NR2A'''] | NR2A (GluN2A) is composed of Amino-terminal domain (ATD), segments S1 and S2 which formed ligand binding domain of glutamate, three transmembrane helices (M1, M3,and M4), cytoplasmic re-entrant pore loop (M2), and an intracellular C-terminal domain (CTD). [[Image:StructureNR2A.jpg#filehistory]| thumb |left|400px| upright=10|'''Structure of NR2A'''] | ||
The ATD is constitued by first 383 aminoacids of NR2A. ATD is an alpha and beta protein class. Structure is bilobed and form clam-shell like structure which consists in two lobes linked by a flexible hinge region defining a central groove. <ref name="ATD clamshell">DOI 10.1038/nsmb.2522</ref> Zn2+ may insert between 2 lobes and induces closure of channel by changing conformation of ATD. Zn increase affinity of glutamate on the LBD which reminds the desensization of AMPA and Kainate receptor. <ref name="Zn">DOI 10.1016/s0896-6273(00)00163-x</ref> | The ATD is constitued by first 383 aminoacids of NR2A. ATD is an alpha and beta protein class. Structure is bilobed and form clam-shell like structure which consists in two lobes linked by a flexible hinge region defining a central groove. <ref name="ATD clamshell">DOI 10.1038/nsmb.2522</ref> Zn2+ may insert between 2 lobes and induces closure of channel by changing conformation of ATD. Zn increase affinity of glutamate on the LBD which reminds the desensization of AMPA and Kainate receptor. <ref name="Zn">DOI 10.1016/s0896-6273(00)00163-x</ref> | ||
