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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
General information
Structure
Location
Important function
Leptin and, therefore, its receptor have multiple roles. Most of these roles have been little developed or are being researched or simply have not been found. However, we do know that it is necessary for the proper development of the human course, as well as its good health. Its main function is linked to the feeling of satiety. This therefore makes it possible not to overeat. It also plays an important role in the use of energy provided by nutrition. Its main role is therefore linked to its production, since the level of leptin depends on the body mass of the person. The stronger a person is, the more leptin they produce. It therefore has a strong link with obesity.
The second important role of the leptin receptor is the development of the body for reproduction and then during pregnancy. Regarding reproduction, studies have shown in mice that the absence of leptin had an impact on their fertility. In particular, because they do not produce enough primary follicles, the size of the uterus is smaller than normal in women, and there is too little sperm production in men due to poor regulation.
For pregnancy, there are two phenomena, one in the mother and the other in the fetus. In the mother there is a significant increase in leptin production throughout pregnancy and then a return to normal just before childbirth. This increase is due to the production of leptin in the placenta, the produced leptin is transmitted thanks to its receptor which is on the wall.For the child, a small amount is transmitted by the placenta but the fetus is able to manufacture leptin in the same way as adults, that is to say according to their fat mass.
Interactions of the protein through the different signaling pathways
Activation
Signaling pathways
Regulation
Disease
This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:https://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
