Sandbox Reserved 1658: Difference between revisions
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== Function == | == Function == | ||
<p align="justify">Neuropilins are involved in many signaling pathways. They act mainly as co-receptors because of their small cytoplasmic domain, and therefore associate with other receptors to transduce their signals through a cell membrane. Neuropilin-1 is involved in the development of the cardiovascular system, but also in angiogenesis | <p align="justify">Neuropilins are involved in many signaling pathways. They act mainly as co-receptors because of their small cytoplasmic domain, and therefore associate with other receptors to transduce their signals through a cell membrane. Neuropilin-1 is involved in the development of the cardiovascular system, but also in [https://en.wikipedia.org/wiki/Angiogenesis angiogenesis] and [https://en.wikipedia.org/wiki/Organogenesis organogenesis]. It is also involved in the development of some neuronal circuits.</p> | ||
<h5>In cardiovascular development</h5> | <h5>In cardiovascular development</h5> | ||
<p align="justify">In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR binding. | <p align="justify">In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors<ref name="cardiovascular development">PMID: 26451046</ref>. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR<ref name="cardiovascular development"/> binding. | ||
Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. Besides, NRP1 enhances the signalling of the extra-cellular matrix in endothelial cells. | Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. Besides, NRP1 enhances the signalling of the extra-cellular matrix in endothelial cells. | ||
</p> | </p> | ||
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<h5>In neuronal development</h5> | <h5>In neuronal development</h5> | ||
<p align="justify">In neuronal tissues, NRP1 | <p align="justify">In neuronal tissues, NRP1 associates with semaphoring-3A to perform growth cone guidance. It helps guiding axonal growth during the development of the nervous system by mediating the chemorepulsant activity of semaphorin.</p> | ||
<h5>In the immune system</h5> | <h5>In the immune system</h5> | ||
