Sandbox Reserved 1648: Difference between revisions
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== '''Signaling pathways''' == | == '''Signaling pathways''' == | ||
The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the JAK family, which will phosphorylate STAT-like transcription factors at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], PI3K and mTOR pathways. | The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the JAK family, which will phosphorylate STAT-like transcription factors at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways. | ||
