Sandbox Reserved 1648: Difference between revisions

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	== '''Regulation''' ==		== '''Regulation''' ==
	The best known regulation of the leptin receptor is negative regulation by OB-RGRP. The gene encoding the leptin receptor (OB-R) also encodes a second transcript called OB-R gene related protein (OB-RGRP). Stopping the expression of the OB-RGRP gene by interfering RNAs increases the sensitivity of the cells' receptors to leptin <ref>https://www.institutcochin.fr/linstitut/evenements/ob-rgrp-regulateur-negatif-du-recepteur-de-la</ref>. This prevents the development of obesity despite a diet that may be high in fat.		The best known regulation of the leptin receptor is negative regulation by OB-RGRP. The gene encoding the leptin receptor (OB-R) also encodes a second transcript called OB-R gene related protein (OB-RGRP). Stopping the expression of the OB-RGRP gene by interfering RNAs increases the sensitivity of the cells' receptors to leptin <ref> Role of OB-RGRP https://www.institutcochin.fr/linstitut/evenements/ob-rgrp-regulateur-negatif-du-recepteur-de-la</ref>. This prevents the development of obesity despite a diet that may be high in fat.

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