Sandbox Reserved 1656: Difference between revisions

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==Deubiquitinase==

Deubiquitinases are enzymes with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse protein and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the proteasome or lysozyme, influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>

'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are enzymes with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse protein and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the proteasome or lysozyme, influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>

== Generalities ==

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==== Function ====

Deubiquitinases ~~or Deubiquitinating enzymes (DUBs)~~ are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://fr.wikipedia.org/wiki/Ubiquitine ubiquitin] of proteins. These enzymes are thus implicated in the regulation of '''protein degradation'''. Indeed, when a protein is going to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination]. Following this step, mono or poly-ubiquitin is removed from the protein which has been degraded, by deubiquitinase. <ref>PMID:9409543</ref>

Deubiquitinases are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://fr.wikipedia.org/wiki/Ubiquitine ubiquitin] of proteins. These enzymes are thus implicated in the regulation of '''protein degradation'''. Indeed, when a protein is going to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination]. Following this step, mono or poly-ubiquitin is removed from the protein which has been degraded, by deubiquitinase. <ref>PMID:9409543</ref>

==== Families ====

Sandbox Reserved 1656: Difference between revisions

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 ==Deubiquitinase==
 <StructureSection load='4WLP' size='340' side='right' caption='Crystal structure of UCH37-NFRKB Inhibited Deubiquitylating Complex' scene=''>
-Deubiquitinases are enzymes with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse protein and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the proteasome or lysozyme, influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>
+'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are enzymes with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse protein and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the proteasome or lysozyme, influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>
 == Generalities ==
@@ Line 8: / Line 8: @@
 ==== Function ====
-Deubiquitinases or Deubiquitinating enzymes (DUBs) are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://fr.wikipedia.org/wiki/Ubiquitine ubiquitin] of proteins. These enzymes are thus implicated in the regulation of '''protein degradation'''. Indeed, when a protein is going to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination]. Following this step, mono or poly-ubiquitin is removed from the protein which has been degraded, by deubiquitinase. <ref>PMID:9409543</ref>
+Deubiquitinases are key enzymes belonging to the vast group of '''proteases''', allowing the degradation of [https://fr.wikipedia.org/wiki/Ubiquitine ubiquitin] of proteins. These enzymes are thus implicated in the regulation of '''protein degradation'''. Indeed, when a protein is going to be degraded, an enzymatic cascade will add a poly-ubiquitin fragment to the protein. This mechanism is called [https://fr.wikipedia.org/wiki/Ubiquitination ubiquitination]. Following this step, mono or poly-ubiquitin is removed from the protein which has been degraded, by deubiquitinase. <ref>PMID:9409543</ref>
 ==== Families ====