Sandbox Reserved 1660: Difference between revisions

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CD1d protein is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system]. It is involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated<ref>Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ (accessed Jan 14, 2021).</ref>. Thus, the production of cytotoxic molecules such as Th1, Th2, [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma INF-gamma] is triggered by this activation. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].

CD1d protein is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system]. It is involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated<ref>Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ (accessed Jan 14, 2021).</ref>. Thus, the production of cytotoxic molecules such as Th1, Th2, [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma INF-gamma] is triggered by this activation<ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].

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Sandbox Reserved 1660: Difference between revisions

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-CD1d protein is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system]. It is involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated<ref>Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ (accessed Jan 14, 2021).</ref>. Thus, the production of cytotoxic molecules such as Th1, Th2, [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma INF-gamma] is triggered by this activation. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].
+CD1d protein is a molecule of the [https://en.wikipedia.org/wiki/Immune_system immune system]. It is involved in presenting a lipid antigen to NKT cells. Indeed, these proteins are located on the surface of the plasma membrane of [https://en.wikipedia.org/wiki/Antigen-presenting_cell APC cells]. When the recognition between the CD1d bound to its lipid ligand and the [[TCR]] of a NKT cell occurs, the [https://en.wikipedia.org/wiki/Lymphocyte lymphocyte] turns out to be activated<ref>Information, N. C. for B.; Pike, U. S. N. L. of M. R.; BethesdaMD; 20894USA. 3GMQ: Structure of mouse CD1d expressed in SF9 cells, no ligand added https://www.ncbi.nlm.nih.gov/Structure/pdb/3GMQ (accessed Jan 14, 2021).</ref>. Thus, the production of cytotoxic molecules such as Th1, Th2, [[interleukin]]-4 and [https://en.wikipedia.org/wiki/Interferon_gamma INF-gamma] is triggered by this activation<ref>Joyce, S. CD1d and Natural T Cells: How Their Properties Jump-Start the Immune System. CMLS, Cell. Mol. Life Sci. 2001, 58 (3), 442–469. https://doi.org/10.1007/PL00000869.</ref>. Therefore, CD1d proteins are precursors of the adaptive immune reaction which are key activators of the NKT cells. As a result, a deficiency of CD1d proteins may lead to a deficiency of the NKT cells functioning and thus to [https://en.wikipedia.org/wiki/Autoimmune_disease autoimmune diseases] and [https://en.wikipedia.org/wiki/Cancer cancers].
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