Sandbox Reserved 1650: Difference between revisions

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Once iodization and coupling have been performed, endocytosis of the colloid to the lysosome occurs. The TG is proteolyzed by cathepsin proteases<ref>DOI 266(30):20198-20204</ref> [a] and 7 TH are thus released from 14 mono- or di iodinated tyrosines.

The hormone synthesis function of TG is thus particularly linked to its structure. Moreover, research shows that denaturation or a simple modification of its conformation prevents the formation of HT <ref>DOI 10.1016/0005-2795(73)90365-6~~</ref> <ref>DOI 102:82–86~~</ref>. [k]

The hormone synthesis function of TG is thus particularly linked to its structure. Moreover, research shows that denaturation or a simple modification of its conformation prevents the formation of HT <ref>DOI 10.1016/0005-2795(73)90365-6</ref>. [k]

[l]

==== Control ====

The synthesis of HT from TG is stimulated by thyroid stimulating hormone (TSH) secreted by the pituitary gland, a gland of the brain. When the TSH receptor is activated, glycosylations leading to the mono iodination of tyrosines promote the synthesis of T3<ref>DOI 266, 20198-20204~~</ref> <ref>DOI 3182849~~</ref>. b][c]

The synthesis of HT from TG is stimulated by thyroid stimulating hormone (TSH) secreted by the pituitary gland, a gland of the brain. When the TSH receptor is activated, glycosylations leading to the mono iodination of tyrosines promote the synthesis of T3<ref>DOI 266, 20198-20204</ref>. b][c]

On the other hand, if the amount of hormones is too high, a negative feedback is exerted on this process while a small amount of these hormones exerts a positive feedback.

Sandbox Reserved 1650: Difference between revisions

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@@ Line 58: / Line 58: @@
 Once iodization and coupling have been performed, endocytosis of the colloid to the lysosome occurs. The TG is proteolyzed by cathepsin proteases<ref>DOI 266(30):20198-20204</ref> [a] and 7 TH are thus released from 14 mono- or di iodinated tyrosines.
-The hormone synthesis function of TG is thus particularly linked to its structure. Moreover, research shows that denaturation or a simple modification of its conformation prevents the formation of HT <ref>DOI 10.1016/0005-2795(73)90365-6</ref> <ref>DOI 102:82–86</ref>. [k]
+The hormone synthesis function of TG is thus particularly linked to its structure. Moreover, research shows that denaturation or a simple modification of its conformation prevents the formation of HT <ref>DOI 10.1016/0005-2795(73)90365-6</ref>. [k]
 [l]
 ==== Control ====
-The synthesis of HT from TG is stimulated by thyroid stimulating hormone (TSH) secreted by the pituitary gland, a gland of the brain. When the TSH receptor is activated, glycosylations leading to the mono iodination of tyrosines promote the synthesis of T3<ref>DOI 266, 20198-20204</ref> <ref>DOI 3182849</ref>. b][c]
+The synthesis of HT from TG is stimulated by thyroid stimulating hormone (TSH) secreted by the pituitary gland, a gland of the brain. When the TSH receptor is activated, glycosylations leading to the mono iodination of tyrosines promote the synthesis of T3<ref>DOI 266, 20198-20204</ref>. b][c]
 On the other hand, if the amount of hormones is too high, a negative feedback is exerted on this process while a small amount of these hormones exerts a positive feedback.