Sandbox Reserved 1649: Difference between revisions

The ATD is constitued by first 383 aminoacids of NR2A. ATD is an alpha and beta protein class. Structure is bilobed and form clam-shell like structure which consists in two lobes linked by a flexible hinge region defining a central groove. <ref name="ATD clamshell">DOI 10.1038/nsmb.2522</ref> Zn2+ may insert between 2 lobes and induces closure of channel by changing conformation of ATD. Zn increase affinity of glutamate on the LBD which reminds the desensitization of AMPA and Kainate receptor.  <ref name="Zn">DOI 10.1016/s0896-6273(00)00163-x</ref> <ref name="ATD RE">DOI 10.1051/medsci/201026165</ref>

ATD allow to modulate NMDA receptor. Difference between différents NR2 is mainly regulated by ATD because diversity of ATD can modulate traffic in endoplasmic reticulum and then affect the localisation of NMDAr. ATD of NR2A increase glutamate affinity, control channel’s opening with high probability and open duration, control glutamate deactivation time course.<ref name="ATD function">DOI 10.1523/JNEUROSCI.1365-09.2009</ref>

'''Ligand binding domain (LBD)'''