Sandbox Reserved 1650: Difference between revisions

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=== Structure of hormonogenic sites ===

Hormonogenic sites are responsible for the formation of one HT each. They are formed by 2 or even 3 tyrosines at less than 15 Å from each other, and exposed to the solvent. Of these tyrosines, 1 or 2 are acceptors and 1 is a donor.

Hormonogenic sites are responsible for the formation of one TH each. They are formed by 2 or even 3 tyrosines at less than 15 Å from each other, and exposed to the solvent. Of these tyrosines, 1 or 2 are acceptors and 1 is a donor.

There are 7 hormonogenic sites for TG :

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two D sites, comprising a Y108 donor and a Y1310 acceptor [[https://www.youtube.com/watch?v=JYUPk59lVVw&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=2>Site D]]

An acidic Asp or Glu residue always precedes the acceptor and a lysine is always close to the donor.

An acidic Asp (aspartic acid) or Glu (glutamic acid) residue always precedes the acceptor and a lysine is always close to the donor.

Except for site C, donors are at the fixed regions of the dimer while acceptors are at the flexible regions.

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=== Use of TG to treat deseases ===

A classic TSH-stimulated Tg measurement or ultrasensitive Tg measurement allows to control its rate in a more or less sensitive way and therefore to detect a disease like those mentioned above, to ensure the effectiveness of a treatment and the absence of recurrence and to avoid

A classic TSH-stimulated TG measurement or ultrasensitive TG measurement allows to control its rate in a more or less sensitive way and therefore to detect a disease like those mentioned above, to ensure the effectiveness of a treatment and the absence of recurrence and to avoid

miscarriages.

Since serum Tg levels are correlated with the volume of thyroid tissue, we can also estimate the mass of thyroid tissue to detect hyperthyroidism, a disease related to an enlarged thyroid or, conversely, hypothyroidism.

Since serum TG levels are correlated with the volume of thyroid tissue, we can also estimate the mass of thyroid tissue to detect hyperthyroidism, a disease related to an enlarged thyroid or, conversely, hypothyroidism.

For example, thyroidectomy and a 131I therapy can be performed to cure thyroid cancer with an 80% chance. Following removal and 131I therapy, thyroglobulin is this time produced by malignant thyrocytes. As a result, its blood level is indistinguishable from that of a healthy person.

Sandbox Reserved 1650: Difference between revisions

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@@ Line 34: / Line 34: @@
 === Structure of hormonogenic sites ===
-Hormonogenic sites are responsible for the formation of one HT each. They are formed by 2 or even 3 tyrosines at less than 15 Å from each other, and exposed to the solvent. Of these tyrosines, 1 or 2 are acceptors and 1 is a donor.
+Hormonogenic sites are responsible for the formation of one TH each. They are formed by 2 or even 3 tyrosines at less than 15 Å from each other, and exposed to the solvent. Of these tyrosines, 1 or 2 are acceptors and 1 is a donor.
 There are 7 hormonogenic sites for TG :
@@ Line 42: / Line 42: @@
 two D sites, comprising a Y108 donor and a Y1310 acceptor [[https://www.youtube.com/watch?v=JYUPk59lVVw&list=PLMGnv0h7EIJydYifu7JSxrkXMzpwlkyDF&index=2>Site D]]
-An acidic Asp or Glu residue always precedes the acceptor and a lysine is always close to the donor.
+An acidic Asp (aspartic acid) or Glu (glutamic acid) residue always precedes the acceptor and a lysine is always close to the donor.
 Except for site C, donors are at the fixed regions of the dimer while acceptors are at the flexible regions.
@@ Line 77: / Line 77: @@
 === Use of TG to treat deseases ===
-A classic TSH-stimulated Tg measurement or ultrasensitive Tg measurement allows to control its rate in a more or less sensitive way and therefore to detect a disease like those mentioned above, to ensure the effectiveness of a treatment and the absence of recurrence and to avoid
+A classic TSH-stimulated TG measurement or ultrasensitive TG measurement allows to control its rate in a more or less sensitive way and therefore to detect a disease like those mentioned above, to ensure the effectiveness of a treatment and the absence of recurrence and to avoid
 miscarriages.
-Since serum Tg levels are correlated with the volume of thyroid tissue, we can also estimate the mass of thyroid tissue to detect hyperthyroidism, a disease related to an enlarged thyroid or, conversely, hypothyroidism.
+Since serum TG levels are correlated with the volume of thyroid tissue, we can also estimate the mass of thyroid tissue to detect hyperthyroidism, a disease related to an enlarged thyroid or, conversely, hypothyroidism.
 For example, thyroidectomy and a 131I therapy can be performed to cure thyroid cancer with an 80% chance. Following removal and 131I therapy, thyroglobulin is this time produced by malignant thyrocytes. As a result, its blood level is indistinguishable from that of a healthy person.