Sandbox Reserved 1648: Difference between revisions

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== '''Signaling pathways''' ==

The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.

The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor '''cytokine receptor'''] characteristics. The transduction of the signal by this type of receptor involves the formation of '''multimeric complexes'''. This leads to the recruitment of [https://en.wikipedia.org/wiki/Tyrosine_kinase '''tyrosine kinases'''], in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.

Sandbox Reserved 1648: Difference between revisions

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Revision as of 17:34, 14 January 2021 view source Léane Costa-Roch (talk \| contribs) 67 edits No edit summary ← Older edit		Revision as of 17:37, 14 January 2021 view source Léane Costa-Roch (talk \| contribs) 67 edits No edit summary Newer edit →
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	== '''Signaling pathways''' ==		== '''Signaling pathways''' ==

	The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.		The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor '''cytokine receptor'''] characteristics. The transduction of the signal by this type of receptor involves the formation of '''multimeric complexes'''. This leads to the recruitment of [https://en.wikipedia.org/wiki/Tyrosine_kinase '''tyrosine kinases'''], in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.