Sandbox Reserved 1657: Difference between revisions
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== Relevance == | == Relevance == | ||
The ''Notch'' signaling pathway regulates cell-cell interaction, embryogenesis as well as various other biological functions in adult tissues. It is a highly conserved pathway. Its relevance and clinical significance lie in the mutations in the ''Notch'' gene that have been identified in an extensive range of cancers in mammals. These mutations can change the activity of the pathway rendering it capable of causing various diseases depending on the sub-type of the ''Notch'' receptor and more importantly, causing it to play an oncogenic or tumor-suppressive role. <ref>doi:10.1146/annurev-pathol-052016-100127</ref> | |||
The ''Notch'' signaling pathway has been studied comprehensively and various aspects of this pathway are very well known. Despite this, it is essential to study the pathway further, so as to understand the role it plays in cancer development and explore novel treatment strategies focusing on the ''Notch'' pathway. | |||
== Structural highlights == | == Structural highlights == | ||
