Sandbox Reserved 1662: Difference between revisions
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UCP2 is 309 amino acids long with domains located in the mitochondrial matrix, in the inner mitochondrial membrane and in the intermembrane mitochondrial space. | UCP2 is 309 amino acids long with domains located in the mitochondrial matrix, in the inner mitochondrial membrane and in the intermembrane mitochondrial space. | ||
More precisely it can be described as a chain of six transmembrane helices and three amphipathic helices. The structure consists of three pseudo-repeats in which a transmembrane helix is linked by a loop to an amphipathic helix, followed by another transmembrane alpha helix. <ref>Kream, E., Mitochondrial uncoupling protein 2 [https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html]<ref/> | More precisely it can be described as a chain of six transmembrane helices and three amphipathic helices. The structure consists of three pseudo-repeats in which a transmembrane helix is linked by a loop to an amphipathic helix, followed by another transmembrane alpha helix. <ref> Kream, E., Mitochondrial uncoupling protein 2 [https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html] <ref/> | ||
In addition, transmembrane helices are mainly composed of Hydrophobic amino acids with a lot of alanine, valine and leucine. <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE <ref/> | In addition, transmembrane helices are mainly composed of Hydrophobic amino acids with a lot of alanine, valine and leucine. <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE <ref/> | ||
