Sandbox Reserved 1662: Difference between revisions
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== A regulated protein == | == A regulated protein == | ||
Some electron paramagnetic resonance studies show a changement of conformation in presence of fatty acids with long chains. Fatty acids are necessary to the setting up of the active form of the UCP2. <ref> | Some electron paramagnetic resonance studies show a changement of conformation in presence of fatty acids with long chains. Fatty acids are necessary to the setting up of the active form of the UCP2. <ref>[https://collab.its.virginia.edu/access/content/group/f85bed6c-45d2-4b18-b868-6a2353586804/2/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)-_-/Ch20_Kream_E_Uncoupling_Protein_2_(Mitochondrial)_MitochondrialUncouplingProtein2.html]Kream, E., Mitochondrial uncoupling protein 2 </ref> | ||
It is also observed that the UCP2 is inhibited by GDP. In that a low cellular energy level will favor the production of ATP by the ATP synthase at the end of the respiratory chain instead of uncoupling. Some experiments with mutants show that the GDP binding site is closer to the helices 1 and 4 <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE </ref> | It is also observed that the UCP2 is inhibited by GDP. In that a low cellular energy level will favor the production of ATP by the ATP synthase at the end of the respiratory chain instead of uncoupling. Some experiments with mutants show that the GDP binding site is closer to the helices 1 and 4 <ref>[https://www.uniprot.org/uniprot/P70406] UniProtKB - P70406 UCP2_MOUSE </ref> | ||
