Sandbox Reserved 1648: Difference between revisions
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The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity. | The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity. | ||
In the '''FN III''' domains, there are two conserved cysteines that are crucial for the activation of the receptor. | In the '''FN III''' domains, there are two conserved '''cysteines''' ('''Cys-672 and Cys-751''' <ref>PMID: 15840566</ref>) that are crucial for the activation of the receptor. | ||
In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | ||
