Sandbox Reserved 1657: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
==5CZX== | ==5CZX== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as T-ALL (T-lineage acute lymphoblastic leukemia). T-ALL is characterized by the uncontrolled proliferation of T-cell | The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142501/ T-ALL (T-lineage acute lymphoblastic leukemia)]. T-ALL is characterized by the uncontrolled proliferation of T-cell [https://en.wikipedia.org/wiki/Lymphoblast ymphoblasts] in the blood, the brown marrow and the tissues. | ||
== Function == | == Function == | ||
'''NOTCH family :''' The NOTCH family encodes transmembrane receptor proteins that are involved in cell fate determination during development. In the drosophila <ref name=Drosophila >DOI:10.1126/science.aab0988</ref> adult midgut, intestinal stem | '''[https://www.creative-diagnostics.com/notch-family.htm NOTCH family] :''' The NOTCH family encodes transmembrane receptor proteins that are involved in cell fate determination during development. In the drosophila <ref name=Drosophila >DOI:10.1126/science.aab0988</ref> adult midgut, intestinal stem | ||
cells produce two types of daughter cells, the nutrient-absorbing enterocytes (ECs) and secretory enteroendocrine (ee) cells. Notch signalling between intestinal stem cells and their daughter cells guides cell specification. ISCs with elevated levels of the Notch Delta ligand more primarily activate the Notch signalling pathway in daughter cells and cause them to become ECs. However, ISCs having low levels of Notch Delta ligand direct daughter cells to become ee cells. | cells produce two types of daughter cells, the nutrient-absorbing enterocytes (ECs) and secretory enteroendocrine (ee) cells. Notch signalling between intestinal stem cells and their daughter cells guides cell specification. ISCs with elevated levels of the Notch Delta ligand more primarily activate the Notch signalling pathway in daughter cells and cause them to become ECs. However, ISCs having low levels of Notch Delta ligand direct daughter cells to become ee cells. | ||
The NOTCH gene family in humans <ref name=Function>DOI:10.1038/sj.onc.1203276</ref> has a link with the Drosophila Notch gene. Members of the NOTCH gene family encode transmembrane receptor proteins that are useful to determine the cell fate during development. | The NOTCH gene family in humans <ref name=Function>DOI:10.1038/sj.onc.1203276</ref> has a link with the Drosophila Notch gene. Members of the NOTCH gene family encode transmembrane receptor proteins that are useful to determine the cell fate during development. | ||
