Sandbox Reserved 1650: Difference between revisions
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'''Introduction''' | '''Introduction''' | ||
Human thyroglobulin (TG)[[https://en.wikipedia.org/wiki/Thyroglobulin]] is a precursor of two thyroid hormones [[https://en.wikipedia.org/wiki/Thyroid_hormones]] (TH): tetraiodothyronine or [[thyroxine]] (T4) and [[triiodothyronine (T3)]], two thyroid hormones (TH). Its structure is essential for the diagnosis, treatment and monitoring of thyroid-related diseases. | |||
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=== Structure of hormonogenic sites === | === Structure of hormonogenic sites === | ||
Hormonogenic sites are responsible for the formation of one | Hormonogenic sites are responsible for the formation of one TH each. They are formed by 2 or even 3 tyrosines at less than 15 Å from each other, and exposed to the solvent. Of these tyrosines, 1 or 2 are acceptors and 1 is a donor. | ||
There are 7 hormonogenic sites for <scene name='86/868183/Full_tg/2'>TG</scene> : | There are 7 hormonogenic sites for <scene name='86/868183/Full_tg/2'>TG</scene> : | ||
