Sandbox Reserved 1648: Difference between revisions
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The '''leptin receptor''', like the hormone that binds to it : [https://en.wikipedia.org/wiki/Leptin '''Leptin'''], allows the '''regulation of body weight''' by balancing food intake. However, they also play a role in '''reproduction''', '''immunity''' and '''bone metabolism'''. | The '''leptin receptor''', like the hormone that binds to it : [https://en.wikipedia.org/wiki/Leptin '''Leptin'''], allows the '''regulation of body weight''' by balancing food intake. However, they also play a role in '''reproduction''', '''immunity''' and '''bone metabolism'''. | ||
Here we give an overview of the current structural knowledge of the receptor and its main functions. Without omitting, its activation, its regulation and its link with some pathologies. | Here we give an overview of the current structural knowledge of the receptor and its main functions. Without omitting, its activation, its regulation and its link with some pathologies. | ||
= General informations = | |||
= '''General informations''' = | |||
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During pregnancy, women have an increase of leptin production. The leptin receptor is located on the wall of the placenta.''' Placental leptin''' is, therefore, transmitted to the mother in addition to the normal release which also increases with fat gain. The foetus recovers very little leptin through this pathway, but already uses the receptor which is on the hypothalamus. | During pregnancy, women have an increase of leptin production. The leptin receptor is located on the wall of the placenta.''' Placental leptin''' is, therefore, transmitted to the mother in addition to the normal release which also increases with fat gain. The foetus recovers very little leptin through this pathway, but already uses the receptor which is on the hypothalamus. | ||
= Interactions of the protein = | = '''Interactions of the protein''' = | ||
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= Disease = | = '''Disease''' = | ||
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