Sandbox Reserved 1649: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
== NR2A (2A5S) == | == NR2A (2A5S) == | ||
NR2A is a protein which is a part of [https://en.wikipedia.org/wiki/NMDA_receptor NMDA receptors], heterodimer channels composed of four subunits. Indeed, NMDA receptors are made of the association between two NR2 and two NR1 proteins. NMDA receptors play a key role in mammalian central nervous system, as they act in Ca2+ influx in synapses in response to glutamate and glycine binding. Their role is essential for learning and memory. Variety of NR2 allows modulation of NMDAr. In the other hand, [https://www.youtube.com/watch?fbclid=IwAR163EHEh3RM8BXt-_4aiecrCgkF83HoyOefyU63d_CQwoqN5RHShYfLDnM&v=4-DuvwoH2zQ& | NR2A is a protein which is a part of [https://en.wikipedia.org/wiki/NMDA_receptor NMDA receptors], heterodimer channels composed of four subunits. Indeed, NMDA receptors are made of the association between two NR2 and two NR1 proteins. NMDA receptors play a key role in mammalian central nervous system, as they act in Ca2+ influx in synapses in response to glutamate and glycine binding. Their role is essential for learning and memory. Variety of NR2 allows modulation of NMDAr. In the other hand, [https://www.youtube.com/watch?fbclid=IwAR163EHEh3RM8BXt-_4aiecrCgkF83HoyOefyU63d_CQwoqN5RHShYfLDnM&v=4-DuvwoH2zQ&feat[http://www.example.com link title]ure=youtu.be NMDA receptor is related to AMPA receptor in the same synapse.] | ||
| Line 42: | Line 42: | ||
The binding of Zn2+ on NR2A generates an allosteric modulation of NMDA receptor, leading to its closure. The molecular mechanisms by which the NTD can communicate the inhibitory change of conformation to the rest of the receptor is still unknown. Nevertheless, the LBD was identified as a major intermediate between the NTD to the channel gate. | The binding of Zn2+ on NR2A generates an allosteric modulation of NMDA receptor, leading to its closure. The molecular mechanisms by which the NTD can communicate the inhibitory change of conformation to the rest of the receptor is still unknown. Nevertheless, the LBD was identified as a major intermediate between the NTD to the channel gate. | ||
It seems that H+ would also inhibits NR2A by conformational changes. Then, it has been proposed that zinc exerts its inhibitory action on NR1/NR2A receptors through an enhancement of tonic proton inhibition | It seems that H+ would also inhibits NR2A by conformational changes. Then, it has been proposed that zinc exerts its inhibitory action on NR1/NR2A receptors through an enhancement of tonic proton inhibition. According to this model, the presence of protons is required for zinc inhibition to occur. | ||
'''• Inhibition by CK2 indirectly on NR2A''' | '''• Inhibition by CK2 indirectly on NR2A''' | ||
Casein Kinase 2 (CK2) determines the NR2 subunit content of synaptic NMDA. Indeed, CK2 phosphorylates NR2B subunit in response to activity, what regulates the number of synaptic NR2A and NR2B. Indeed, CK2 phosphorylation leads to NR2B endocytosis and remove NR2B from synapses, resulting in an increase in synaptic NR2A expression. | [https://en.wikipedia.org/wiki/Casein_kinase_2 Casein Kinase 2] (CK2) determines the NR2 subunit content of synaptic NMDA. Indeed, CK2 phosphorylates NR2B subunit in response to activity, what regulates the number of synaptic NR2A and NR2B. Indeed, CK2 phosphorylation leads to NR2B endocytosis and remove NR2B from synapses, resulting in an increase in synaptic NR2A expression. | ||
