Sandbox Reserved 1649: Difference between revisions
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On the contrary, the palmitoylation of the second cluster by distinct palmitoyl transferases causes receptors accumulation in the Golgi apparatus and so reduces receptor surface expression. | On the contrary, the palmitoylation of the second cluster by distinct palmitoyl transferases causes receptors accumulation in the Golgi apparatus and so reduces receptor surface expression. | ||
Since palmitoylation is reversible, by modulating phosphorylation on NR2A thanks to this dual palmitoylation, the traffiking of NMDA receptors can be regulated. Palmitoylation of Cystein cluster I regulates NMDA receptor internalization whereas palmitoylation of Cys cluster II retains the receptor in the Golgi apparatus. It is important because it controls the number of effective NMDA receptors at the surface of the cell, which has an impact on the neuronal function. | Since palmitoylation is reversible, by modulating phosphorylation on NR2A thanks to this dual palmitoylation, the traffiking of NMDA receptors can be regulated. Palmitoylation of Cystein cluster I regulates NMDA receptor internalization whereas palmitoylation of Cys cluster II retains the receptor in the Golgi apparatus. It is important because it controls the number of effective NMDA receptors at the surface of the cell, which has an impact on the neuronal function. <ref name="ATD function">DOI 10.1016/j.neuron.2009.08.017</ref> | ||
