6z1t: Difference between revisions
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==MAP3K14 (NIK) in complex with 4S/3694== | ==MAP3K14 (NIK) in complex with 4S/3694== | ||
<StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]]' scene=''> | <StructureSection load='6z1t' size='340' side='right'caption='[[6z1t]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br> | <table><tr><td colspan='2'>[[6z1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Z1T FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [http://pdbe.org/6z1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [http://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q55:4S/3694'>Q55</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6z1q|6z1q]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP3K14, NIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6z1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1t OCA], [http://pdbe.org/6z1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6z1t RCSB], [http://www.ebi.ac.uk/pdbsum/6z1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1t ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/M3K14_HUMAN M3K14_HUMAN]] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:15084608</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Attar R]] | [[Category: Mitogen-activated protein kinase kinase kinase]] | ||
[[Category: Hynd G]] | [[Category: Attar, R]] | ||
[[Category: Jacoby E]] | [[Category: Hynd, G]] | ||
[[Category: Meerpoel L]] | [[Category: Jacoby, E]] | ||
[[Category: Querolle O]] | [[Category: Meerpoel, L]] | ||
[[Category: Stansfield I]] | [[Category: Querolle, O]] | ||
[[Category: Versele M]] | [[Category: Stansfield, I]] | ||
[[Category: | [[Category: Versele, M]] | ||
[[Category: Vlijmen, H van]] | |||
[[Category: Free energy perturbation]] | |||
[[Category: Jnj64290694]] | |||
[[Category: Lead optimization]] | |||
[[Category: Multiple myeloma]] | |||
[[Category: Nik]] | |||
[[Category: Transferase]] | |||
