Sandbox reserved 1651: Difference between revisions

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The cis-PT catalyze the chain elongation of FPP by successive head-to-tail condensation with a specific number of IPP to form linear lipids with designated chain lengths. The reaction is as follows:

IPP headgroups are bound to the enzyme at the superficial polar region while the carbon chains point toward the deep hydrophobic tunnel. First, the pyrophosphate group (FPP) of the initiatory substrate, which interacts with a Mg<sup>2+</sup> ion, is hydrolyzed at the S1 site. Then, the condensation of remaining carbon with the IPP from S2 site follows. The elongated products translocate to the S1 so the carbon chain goes into the hydrophobic tunnel of the active site. At the end, a new IPP molecule binds to the S2 site and the cycle is repeated until the active site can no longer accommodate the long chain isoprenoid.

IPP headgroups are bound to the enzyme at the superficial polar region while the carbon chains point toward the <scene name='87/872232/Hydrophobic_tunnel/1'>deep hydrophobic tunnel</scene>. First, the pyrophosphate group (FPP) of the initiatory substrate, which interacts with a Mg<sup>2+</sup> ion, is hydrolyzed at the <scene name='87/872232/S1_site/2'>S1 site</scene>. Then, the condensation of remaining carbon with the IPP from S2 site follows. The elongated products translocate to the S1 so the carbon chain goes into the hydrophobic tunnel of the active site. At the end, a new IPP molecule binds to the S2 site and the cycle is repeated until the active site can no longer accommodate the long chain isoprenoid.

=== Regulation of the product length ===

Sandbox reserved 1651: Difference between revisions

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 The cis-PT catalyze the chain elongation of FPP by successive head-to-tail condensation with a specific number of IPP to form linear lipids with designated chain lengths. The reaction is as follows:
-IPP headgroups are bound to the enzyme at the superficial polar region while the carbon chains point toward the deep hydrophobic tunnel. First, the pyrophosphate group (FPP) of the initiatory substrate, which interacts with a Mg<sup>2+</sup> ion, is hydrolyzed at the S1 site. Then, the condensation of remaining carbon with the IPP from S2 site follows. The elongated products translocate to the S1 so the carbon chain goes into the hydrophobic tunnel of the active site. At the end, a new IPP molecule binds to the S2 site and the cycle is repeated until the active site can no longer accommodate the long chain isoprenoid.
+IPP headgroups are bound to the enzyme at the superficial polar region while the carbon chains point toward the <scene name='87/872232/Hydrophobic_tunnel/1'>deep hydrophobic tunnel</scene>. First, the pyrophosphate group (FPP) of the initiatory substrate, which interacts with a Mg<sup>2+</sup> ion, is hydrolyzed at the <scene name='87/872232/S1_site/2'>S1 site</scene>. Then, the condensation of remaining carbon with the IPP from S2 site follows. The elongated products translocate to the S1 so the carbon chain goes into the hydrophobic tunnel of the active site. At the end, a new IPP molecule binds to the S2 site and the cycle is repeated until the active site can no longer accommodate the long chain isoprenoid.
 === Regulation of the product length ===