Sandbox Reserved 1656: Difference between revisions
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==== Families ==== | ==== Families ==== | ||
Deubiquitinases belong to the protease family. This family is divided into '''five classes''', according to the nature of the amino acid composition of their active site carrying out the catalysis: serine protease, [https:// | Deubiquitinases belong to the protease family. This family is divided into '''five classes''', according to the nature of the amino acid composition of their active site carrying out the catalysis: serine protease, [https://en.wikipedia.org/wiki/Cysteine_protease cysteine proteases], acid proteases, metalloproteases, threonine proteases. DUBs belong to only two of these families: '''metalloproteases''' and '''cysteine proteases'''. | ||
Among the cysteine proteins, four subfamilies can be described according to their catalytic domains: ubiquitin-specific proteases (USP), les Ubiquitin C-terminal hydrolases (UCH), Otubain proteases (OTU) and Machado-joseph disease proteases (MJD). The deubiquitinases belonging to the family of metalloproteases all have a JAMM catalytic domain (JAB1/MPN/Mov34 metalloenzyme). | Among the cysteine proteins, four subfamilies can be described according to their catalytic domains: ubiquitin-specific proteases (USP), les Ubiquitin C-terminal hydrolases (UCH), Otubain proteases (OTU) and Machado-joseph disease proteases (MJD). The deubiquitinases belonging to the family of metalloproteases all have a JAMM catalytic domain (JAB1/MPN/Mov34 metalloenzyme). | ||
Within these two families, DUBs are classified into subfamilies according to the differences in their amino acid sequences surrounding the catalytically active amino acid residues. <ref>PMID:15571815</ref> | Within these two families, DUBs are classified into subfamilies according to the differences in their amino acid sequences surrounding the catalytically active amino acid residues. <ref>PMID:15571815</ref> | ||
