Sandbox Reserved 1656: Difference between revisions
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{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
== | ==Deubiquitinases== | ||
<StructureSection load='3TMP' size='340' side='right' caption='The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde' scene=''> | <StructureSection load='3TMP' size='340' side='right' caption='The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde' scene=''> | ||
'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse [https://en.wikipedia.org/wiki/Protein protein] and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref> | '''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse [https://en.wikipedia.org/wiki/Protein protein] and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref> | ||
