Sandbox Reserved 1646: Difference between revisions
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Conformational rearrangements of common microswitches<ref>DOI: 10.7554/eLife.28505</ref> are characteristically influenced by the unusual ligand recognition and the absence of the cytoplasmic C-terminal helix. | Conformational rearrangements of common microswitches<ref>DOI: 10.7554/eLife.28505</ref> are characteristically influenced by the unusual ligand recognition and the absence of the cytoplasmic C-terminal helix. | ||
The transition of different GPCR conformation states is known to be mediated by water molecules by rearranging the conserved hydrophilic network formed by conserved amino acids in different helices <ref>DOI: 10.1073/pnas.1809251116</ref>. | The transition of different GPCR conformation states is known to be mediated by water molecules by rearranging the conserved hydrophilic network formed by conserved amino acids in different helices<ref>DOI: 10.1073/pnas.1809251116</ref>. | ||
Different motifs have been identified to be critical for signal transmission in GnH1R. Noteworthy, the hydrophobic Y6.51-Y6.52(TM6)-W6.48-F6.44 motif in TM6 and residues F272 and Y323. | Different motifs have been identified to be critical for signal transmission in GnH1R. Noteworthy, the hydrophobic Y6.51-Y6.52(TM6)-W6.48-F6.44 motif in TM6 and residues F272 and Y323<ref>DOI: 10.1038/s41467-020-19109-w</ref>. | ||
==Gonadotropin releasing hormone== | ==Gonadotropin releasing hormone== | ||
